Cannabinoid Type-1 Receptor Reduces Pain and Neurotoxicity Produced by Chemotherapy
نویسندگان
چکیده
منابع مشابه
Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy.
Painful peripheral neuropathy is a dose-limiting complication of chemotherapy. Cisplatin produces a cumulative toxic effect on peripheral nerves, and 30-40% of cancer patients receiving this agent experience pain. By modeling cisplatin-induced hyperalgesia in mice with daily injections of cisplatin (1 mg/kg, i.p.) for 7 d, we investigated the anti-hyperalgesic effects of anandamide (AEA) and cy...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0403-12.2012